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Noticias de Crohn - Copy.png

Mais um comparativo entre vários possíveis tratamentos para a doença de Crohn.

 

Resumo na língua original:

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To compare the proportion of patients who achieved induction of remission with different therapeutic options, Kaplan and colleagues reviewed randomized controlled trial data published up to November 2015, and ultimately analyzed 22 trials comparing budesonide, sulfasalazine, mesalamine or corticosteroids with each other or placebo. They also stratified mesalamine and budesonide into low and high doses.

 

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They found that corticosteroids were the most effective compared with placebo (OR = 3.8; 95% CI, 2.48-5.66) followed by high-dose budesonide above 6 g daily (OR = 2.96; 95% CI, 2.06-4.3).

 

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Furthermore, they found that high-dose mesalamine was superior to placebo for induction of remission (OR = 2.29; 95% CI, 1.58-3.33).

 

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While corticosteroids were comparably effective to high-dose budesonide (OR = 1.21; 95% CI, 0.84–1.76), they were more effective than high-dose mesalamine (OR = 1.83; 95% CI, 1.16–2.88). Finally, they found that sulfasalazine was not significantly more effective than other therapies or placebo.

 

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